Limited Weight Loss or Simply No Weight Gain following Lifestyle-Only Intervention Tends to Redistribute Body Fat, to Decrease Lipid Concentrations, and to Improve Parameters of Insulin Sensitivity in Obese Children

نویسندگان

  • Henry Marcano
  • Maricelia Fernández
  • Mariela Paoli
  • Mercedes Santomauro
  • Nolis Camacho
  • Rosanna Cichetti
  • Zarela Molina
  • Lenin Valeri
  • Roberto Lanes
چکیده

Objectives. To investigate whether lifestyle-only intervention in obese children who maintain or lose a modest amount of weight redistributes parameters of body composition and reverses metabolic abnormalities. Study Design. Clinical, anthropometric, and metabolic parameters were assessed in 111 overweight or obese children (CA of 11.3 ± 2.8 years; 63 females and 48 males), during 8 months of lifestyle intervention. Patients maintained or lost weight (1-5%) (group A; n: 72) or gained weight (group B). Results. Group A patients presented with a decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) (P < .005 and P < .05, resp.), BMI (P < .0001), z-score BMI (P < .0001), waist circumference (P < .0001), fat mass (P < .005), LDL-C (P < .05), Tg/HDL-C ratio (P < .05), fasting and postprandial insulin (P < .005), and HOMA (P < .005), while HDL-C (P < .05) and QUICKI increased (P < .005). Conversely, group B patients had an increase in BMI (P < .0001), waist circumference (P < .005), SBP (P < .005), and in QUICKI (P < .005), while fat mass (P < .05), fasting insulin (P < .05), and HOMA (P < .05) decreased. Lean mass, DBP, lipid concentrations, fasting and postprandial glucose, postprandial insulin, and ultrasensitive C-reactive protein (CRP) remained stable. Conclusions. Obese children who maintain or lose a modest amount of weight following lifestyle-only intervention tend to redistribute their body fat, decrease blood pressure and lipid levels, and to improve parameters of insulin sensitivity.

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منابع مشابه

Clinical Study LimitedWeight Loss or Simply NoWeight Gain following Lifestyle-Only Intervention Tends to Redistribute Body Fat, to Decrease Lipid Concentrations, and to Improve Parameters of Insulin Sensitivity in Obese Children

Objectives. To investigate whether lifestyle-only intervention in obese children who maintain or lose a modest amount of weight redistributes parameters of body composition and reverses metabolic abnormalities. Study Design. Clinical, anthropometric, and metabolic parameters were assessed in 111 overweight or obese children (CA of 11.3± 2.8 years; 63 females and 48 males), during 8 months of li...

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عنوان ژورنال:

دوره 2011  شماره 

صفحات  -

تاریخ انتشار 2011